| Abbreviation | Definition |
|---|---|
| MDCS | Malfunction Display and Control System |
| MDCS | Master Digital Command System |
| MDCS | Material Data Collection System |
| MDD | Mate/Demate Device |
| MDDS | Material Directory Data Sheet |
| MDE | Mission Dependent Equipment |
| MDE | Mission Dependent Experiment |
| MDE | Modular Display Electronics |
| MDF | Main Distribution Frame |
| MDF | Manipulator Development Facility |
| MDF | Mating/Demating Facilities |
| MDF | Mild Detonating Fuse |
| MDI | Michelson Doppler Imager |
| MDIF | Mission Data Integration Facility |
| MDI-H | Michelson Doppler Imager- Helioseismology |
| MDI-M | Michelson Doppler Imager- Magnetogram |
| MDL | Master Data Library |
| MDM | Manipulator Deployment Mechanism |
| MDM | Medical Monitor |
| MDM | Multiplexer/Demultiplexer |