| Abbreviation | Definition |
|---|---|
| MDM | Multiplexer/De-Multiplexer |
| MDR | Maintenance Demand Rate |
| MDR | Major Design Review |
| MDR | Minor Discrepancy Repair |
| MDR | Missing Data Report |
| MDR | Mission Data Reduction |
| MDR | Monthly Director's Review |
| MDRD | Mission Data Requirements Document |
| MDRS | Manufacturing Data Retrieval System |
| MDRS | Mission Data Retrieval System |
| MDS | Malfunction Detection System |
| MDS | Management Data System |
| MDS | Master Development Schedule |
| MDS | Minimum Discernible Signal |
| MDS | Minimum Discernible System |
| MDS | Mission Design Series |
| MDS | Mission Development Simulator |
| MDS | Motion Detection System |
| MDSCC | Madrid Deep Space Communication Complex |
| MDSD | Mate/Demate Stiffleg Derrick |