| Abbreviation | Definition |
|---|---|
| SMA | Secondary Mirror Assembly |
| SMAB | Solid Motor Assembly Building |
| SMAG | Star Magnitude |
| SMART | Satellite Multimedia Applications Research and Trials |
| SMART | Shared Mobile Atmospheric Research and Teaching |
| SMART | Shuttle Meeting Action - Item Review Tracking |
| SMART | Small Missions for Advanced Research and Technolgy |
| SMART | Small Missions For Advanced Research And Technology |
| SMATV | Satellite Master Antenna Television |
| SMB | Space Meteorology Branch |
| SMC | Scientific Manpower Commission |
| SMC | Spatial Motion Compensation |
| SMCC | Shuttle Mission Control Center |
| SMCH | Standard Mixed Cargo Harness |
| SMCS | Separation Monitor and Control System |
| SMCU | Separation Monitoring Control Unit |
| SMD | Science Mission Directorate |
| SMD | Spacelab Mission Development |
| SMD | Special Measuring Device |
| SMDC | Shielded Mild Detonating Cord |