| Abbreviation | Definition |
|---|---|
| SME | Subject Matter Expert |
| SMEAR | Span/Mission Evaluation Action Request |
| SMES | Shuttle Mission Engineering Simulator |
| SMES | Shuttle Mission Evaluation Simulation (Simulator) |
| SMES | Shuttle Mission Evaluation Simulator |
| SMES | Superconduction Magnetic Energy Storage |
| SMG | Spaceflight Meteorology Group |
| SMIA | Serial Multiplexer Interface Adapter |
| SMIDEX | Spacelab MIDdeck EXperiment |
| SMIP | SOHO Mission Implementation Plan |
| SMIR | Shuttle Multispectral Infrared Radiometer |
| SMIRD | SOHO Mission Implementation Requirements Document |
| SML | Structure Mold Line |
| SMM | Solar Maximum Mission |
| SMM | Subsystem Measurement Management |
| SMM | Surface Mount Module |
| SMMD | Specimen Mass Measurement Device |
| SMO | System Management Office |
| SMOC | Simulation Mission Operation Computer |
| SMOC | SOHO Science and Mission Operations Center |