| Abbreviation | Definition |
|---|---|
| SNR | Signal-to-Noise Ratio |
| SNS | Station Network Simulator |
| SNSO | Space Nuclear Systems Office |
| SNSR | Sensor |
| SNU | Solar Neutrino Unit |
| SO | Station Operator |
| SO | Support Operations |
| SO | Support Operations (KSC Dir.) |
| SO2 | Sulphur Dioxide |
| SOAR | Shuttle Orbital Applications and Requirements |
| SOARS | Shuttle Operation Automated Reporting System |
| SOATS | Support Operation Automated Training System |
| SOBER | Small Object Bearing Effect Reductiveness |
| SOC | Science Operations Center |
| SOC | Science Operations Coordinator |
| SOC | Simulated Operation Computer |
| SOC | Simulation Operations Center |
| SOC | Simulations Operations Center |
| SOC | System Operating Concept |
| SOC | System Option Controller |