| Abbreviation | Definition |
|---|---|
| SOCA | Special Operations Control Area |
| SOCAR | Shuttle Operational Capability Assessment Report |
| SOCC | Satellite Operations Control Center |
| SOCH | Spacelab Orbiter Common Hardware |
| SOCRD | Science Operations Center Requirements Document |
| SOCS | Subsystem Operation and Checkout System |
| SODA | Solar Observational Data For Applications |
| SODB | Shuttle Operational Data Book |
| SODB | Start of Data Block |
| SODS | Shuttle Operational Data System |
| SODS | Skylab Orbit-Deorbit System |
| SOE | Science Operations Element |
| SOF | Safety Of Flight |
| SOFI | Spray-on Foam Insulation |
| SOFIA | Stratospheric Observatory For Infrared Astronomy |
| SOFT | Space Operations and Flight Techniques |
| SOG | Speed Over the Ground |
| SOGS | Science Operations Ground System |
| SOH | Start of Heading |
| SOHO | Solar and Heliospheric Observatory |