| Abbreviation | Definition |
|---|---|
| SPR | Subcontractor Performance Review |
| SPRAG | STS Payloads Requirements and Analysis Group |
| SPRT | Sequential Probability Ratio Test |
| SPS | Samples Per Second |
| SPS | Secondary Propulsion System |
| SPS | Service Propulsion Subsystem |
| SPS | Service Propulsion System |
| SPS | Shuttle Procedures Simulator |
| SPS | Solar Power Satellite |
| SPS | Solar Powered Satellite |
| SPS | Statement of Prior Submission |
| SPS | Symbols per second |
| SP-SMO | Site Management Office (KSC Shuttle) |
| SP-SMO | Site Management Office of the Shuttle Projects Office directorate |
| SPT | Steering Position Transducer |
| SPTD | Supplemental Provisioning Technical Documentation |
| SPTN | Shuttle Pointed Autonomous Research Tool for Astronomy (NASA; aka SPARTAN) |
| SPU | S-band Polar Ultra |
| SPU | Solar Panel Unit |
| SPU | Special Parts Used |