| Abbreviation | Definition |
|---|---|
| SPO | System Program Office |
| SPOC | Shuttle Payload Operations Contractor |
| SPOF | Science Planning and Operations Facility |
| SPOM | STS Planning and Operations Management |
| SP-OPI | Operations Planning and Integration Office (KSC Shuttle) |
| SP-OPI | Operations Planning and Integration Office of the Shuttle Projects Office directorate |
| SP-OSO | Off-Site Offices (KSC Shuttle) |
| SP-OSO | Off-Site Offices of the Shuttle Projects Office directorate |
| SPP | Science Power Platform |
| SPP | Simulation Planning Panel |
| SPP | Solar Physics Payload |
| SP-PAI | Project Assessment and Integration Staff (KSC) |
| SP-PAI | Project Assessment and Integration Staff of the Shuttle Projects office directorate |
| SP-PCO | Program Control Office (KSC Shuttle) |
| SP-PCO | Program Control Office of the Shuttle Projects Office directorate |
| SPPIL | Shuttle Preferred Pyrotechnic Items List |
| SPPL | Spare Parts Provisioning List |
| SP-PMS | Performance Management Systems Office (KSC) |
| SP-PMS | Performance Management Systems Office of the Shuttle Projects office directorate |
| SPPP | Spacelab Payloads Processing Project |