| Abbreviation | Definition |
|---|---|
| SOT | Science Operations Team |
| SOT | Sea Of Tranquility |
| SOT | Solar Optical Telescope |
| SOT | Strap-on Tank |
| SOTA | Science Operations and Test Area |
| SOTS | Suborbital Tank Separation |
| SOUP | Solar Optical Universal Photopolarimeter |
| SOV | Shut-Off Valve |
| SOV | Solenoid Operated Valve |
| SOW | Start of Word |
| SOW | Subdivision of Work |
| SOWG | SOHO Science Operations Working Team |
| SOX | Supercritical Oxygen |
| SP | Shoulder Pitch |
| SP | Shuttle Projects Office |
| SP | Shuttle Projects Office (KSC) |
| SP | Signal Processor |
| SP | Single Pole |
| SP | Single Precision |
| SP | Solar Physics |