| Abbreviation | Definition |
|---|---|
| SPD | Standard Practice Directive |
| SPDB | Subsystem Power Distribution Box |
| SPDBK | Speed Brake |
| SPDCI | Standard Payload Display and Control Interface |
| SPDR | Software Preliminary Design Review |
| SPE | Solid Polymer Electrolysis |
| SPE | Static Phase Error |
| SPEARS | Shuttle Processing Electronic Archival & Retrieval System |
| SPEC | Specialist Function |
| SPEC | Standard Performance Evaluation Corporation |
| SPECT | SPECTrometer |
| SPEE | Special Purpose End Effector |
| SPF | Single Point Failure |
| SPF | Software Production Facility |
| SPF | Spacelab Processing Facility |
| SPFA | Single Point Failure Analysis |
| SP-FGS | Flight and Ground Systems Office (KSC Shuttle) |
| SP-FGS | Flight and Ground Systems Office of the Shuttle Projects Office directorate |
| SPFP | Single Point Failure Potential |
| SPG | Signal Point Ground |