| Abbreviation | Definition |
|---|---|
| SPG | Single Point Ground |
| SPHER | Spherical |
| SPI | Standard Practice Instruction |
| SPI | Surface Position Indicator |
| SPIAP | Shuttle/Payload Integration Activities Plan |
| SPIC | Space Programs Information Coalition |
| SPICE | Spacecraft Planets Instrument Constants And Events |
| SPICE | Spacelab Payload Integration and Coordination in Europe |
| SPIDF | Support Planning Identification File |
| SPIDPO | Shuttle Payload Integration and Development Program Office (JSC) |
| SPIF | Shuttle Payload Integration Facility |
| SPIF | Shuttle/POCC Interface Facility Function |
| SPIF | Standard Payload Interface Facility |
| SPII | Shuttle Program Implementation Instruction |
| SP-ILS | Integrated Logistics Support Office (KSC Shuttle) |
| SP-ILS | Integrated Logistics Support Office of the Shuttle Projects directorate |
| SPIMS | Shuttle Program Information Management System |
| SPIP | Solid Propulsion Integrity Program |
| SPIS | Spacecraft Plasma Interaction System |
| SPK | Spacecraft And Planet Kernel |